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Author:senvera
Copyright:Prohibited republication
Corrector's skills: Native, Perfect
Tags: chromosome 3p
Language: English
Progress: processing: 0, ready corrections: 0, remains corrections: 1

Identification of novel cancer significant genes opens new broad possibilities for early diagnostics, prognosis and correction of treatment of epithelial tumors, which are the most prevalent and lethal cancers in the world. Screening of chromosome 3p genes was well founded by the authors. Indeed, chromosome 3p deletions were detected in almost 100% of SCLC, RCC and in more than 90% of NSCLC. Chromosome transfer experiments indicated that different regions of 3p could suppress the tumorigenic properties of cancer cell lines and could harbor several tumor suppressor genes (TSG). However, although the presence of TSG in 3p was suggested in late 80ties the first TSG was identified only in 2000 (excluding VHL). The authors were among the researchers who first identified TSGs in 3p.









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